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The nicotinic acetylcholine receptors (nAChRs) on VSMCs nAChRs are transmembrane ligand-gated ion channels expressed in the cell membrane of all mammalian cells, and their endogenous ligand is acetylcholine [26]

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In recent congressional testimony, JUUL officials attempted to have it both ways by claiming it was intended to help smokers stop smoking and that it was not a cessation product. The industry also implies that its smoke-free products are preferable to the public health strategies that we know to be effective